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HelpTest Code WBSQR Beta-Globin Gene Sequencing, Blood
Specimen Required
Only orderable as a reflex. For more information see:
-HAEV1 / Hemolytic Anemia Evaluation, Blood
-HBEL1 / Hemoglobin Electrophoresis Evaluation, Blood
-MEV1 / Methemoglobinemia Evaluation, Blood
-REVE2 / Erythrocytosis Evaluation, Blood
-THEV1 / Thalassemia and Hemoglobinopathy Evaluation, Blood and Serum
Specimen Type: Whole blood
Container/Tube:
Preferred: Lavender top (EDTA)
Acceptable: Yellow top (ACD)
Specimen Volume: 4 mL
Useful For
Evaluating for the following in an algorithmic process for the HAEV1 / Hemolytic Anemia Evaluation, Blood; HBEL1 / Hemoglobin Electrophoresis Evaluation, Blood; MEV1 / Methemoglobinemia Evaluation, Blood; REVE2 / Erythrocytosis Evaluation, Blood; THEV1 / Thalassemia and Hemoglobinopathy Evaluation, Blood and Serum:
-Diagnosing of beta thalassemia intermedia or major
-Identifying a specific beta thalassemia sequence variant (ie, unusually severe beta thalassemia trait)
-Evaluating an abnormal hemoglobin electrophoresis identifying a rare beta-globin variant
-Evaluating chronic hemolytic anemia of unknown etiology
-Evaluating hereditary erythrocytosis with left-shifted p50 oxygen dissociation results
-Preconception screening when there is a concern for a beta-hemoglobin disorder based on family history
Reporting Name
Beta Globin Gene Sequencing, BSpecimen Type
Whole Blood EDTASpecimen Minimum Volume
1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Whole Blood EDTA | Refrigerated | 14 days |
Reject Due To
| Gross hemolysis | OK |
| Moderately to severely clotted | Reject |
Reference Values
Only orderable as a reflex. For more information see:
-HAEV1 / Hemolytic Anemia Evaluation, Blood
-HBEL1 / Hemoglobin Electrophoresis Evaluation, Blood
-MEV1 / Methemoglobinemia Evaluation, Blood
-REVE2 / Erythrocytosis Evaluation, Blood
-THEV1 / Thalassemia and Hemoglobinopathy Evaluation, Blood and Serum
An interpretive report will be provided.
Day(s) Performed
Monday through Friday
Report Available
10 daysSpecimen Retention Time
Blood: 2 weeks; DNA: 3 monthsPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
81364-HBB (hemoglobin, beta) full sequence
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| WBSQR | Beta Globin Gene Sequencing, B | 50996-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 47954 | Beta Globin Gene Sequencing Result | 50397-9 |
| 47955 | Interpretation | 59466-3 |