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HelpTest Code VZPG Varicella-Zoster Antibody, IgG, Serum
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Reporting Name
Varicella-Zoster Ab, IgG, SSpecimen Type
SerumSpecimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
| Heat-inactivated specimen | Reject |
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days |
Specimen Minimum Volume
0.4 mL
Day(s) Performed
Monday through Saturday
Specimen Retention Time
14 daysReport Available
Same day/1 to 3 daysReference Values
Vaccinated: Positive (≥1.1 antibody index [AI])
Unvaccinated: Negative (≤0.8 AI)
Reference values apply to all ages.
Useful For
Determination of immune status of individuals to the varicella-zoster virus (VZV)
Documentation of previous infection with VZV in an individual without a previous record of immunization to VZV
CPT Code Information
86787
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| VZPG | Varicella-Zoster Ab, IgG, S | 15410-4 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| VZG | Varicella-Zoster Ab, IgG, S | 15410-4 |
| DEXG4 | Varicella IgG Antibody Index | 5403-1 |
Supportive Data
To evaluate the accuracy of the BioPlex Varicella-Zoster Virus (VZV) IgG multiplex flow immunoassay, 500 prospective serum samples were analyzed in a blinded fashion by the Diamedix VZV IgG enzyme immunoassay (EIA) (Diamedix) and the BioPlex VZV IgG assay. Samples with discordant results after initial testing were repeated by both assays during the same freeze/thaw cycle. Further discrepancies were evaluated by the SeraQuest VZV IgG EIA.(Quest International) The results are summarized in the Table below:
Table. Comparison between Bioplex and Diamedix Varicella-Zoster Virus (VZV) Assays
|
Diamedix VZV IgG EIA |
||||
|
BioPlex VZV IgG |
|
Positive |
Negative |
Equivocal |
|
Positive |
436 |
0 |
0 |
|
|
Negative |
18(a) |
22 |
4 |
|
|
Equivocal |
19 |
0 |
1 |
|
a. All 18 specimens tested positive by the SeraQuest VZV IgG EIA.
Sensitivity: 92.2% (436/473); 95% CI: 89.4%-94.3%
Specificity: 100.0 (22/22); 95% CI: 82.5%-100.0%
Overall percent agreement: 91.8% (459/500); 95% CI: 89.0%-93.9%
Forms
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-General Request (T239)