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Test Code PCPRO Plasma Cell DNA Content and Proliferation, Bone Marrow

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Reporting Name

Plasma Cell Proliferation, Marrow

Specimen Type

Bone Marrow


Ordering Guidance


This test can be ordered at diagnosis or follow-up of a plasma cell neoplasm (plasma cell proliferative disorder).

 

If reflex fluorescence in situ hybridization (FISH) testing is desired, order MSMRT / Mayo Algorithmic Approach for Stratification of Myeloma and Risk-Adapted Therapy Report, Bone Marrow.

 

For follow-up of a plasma cell neoplasm (plasma cell proliferative disorder), order MSMRD / Myeloma Stratification and Risk-Adapted Therapy with Reflex to Measurable/Minimal Residual Disease, Bone Marrow, could be considered.



Necessary Information


Include patient's disease state (untreated, treated, monoclonal gammopathy of undetermined significance, stable).



Specimen Required


Specimen Type: Redirected bone marrow

Preferred: Yellow top (ACD solution A or B)

Acceptable: Lavender top (EDTA) or green top (sodium heparin)

Specimen Volume: 4 mL

Specimen Stability Information: 3 days


Reject Due To

Gross hemolysis Reject
Fully clotted Reject

Specimen Stability Information

Specimen Type Temperature Time
Bone Marrow Ambient (preferred)
  Refrigerated 

Specimen Minimum Volume

2 mL

Day(s) Performed

Monday through Saturday

Specimen Retention Time

14 days

Report Available

1 to 4 days

Reference Values

Plasma Cell Clonality:

Normal bone marrow

No monotypic clonal plasma cells detected

 

DNA Index:

Normal polytypic plasma cells

DNA index (G0/G1 cells): Diploid 0.95-1.05

Additional Tests

Test ID Reporting Name Available Separately Always Performed
FCINT Flow Cytometry Interp, 2-8 Markers No, (Bill Only) Yes

Useful For

Establishing a diagnosis of a plasma cell proliferative disorder

 

Providing prognostic information for newly diagnosed multiple myeloma and other plasma cell proliferative disorders

 

Assessing response to therapy and detecting disease relapse and progression in treated plasma cell proliferative disorder patients

 

Determining plasma cell DNA content and proliferation

Testing Algorithm

When this test is ordered, flow cytometry interpretation will always be performed at an additional charge.

 

For more information see:

-Amyloidosis: Laboratory Approach to Diagnosis

-Multiple Myeloma: Laboratory Screening

CPT Code Information

88182-Flow cytometry, cell cycle or DNA analysis

88184-Flow cytometry; first cell surface, cytoplasmic or nuclear marker

88185 x 5-Flow cytometry; additional cell surface, cytoplasmic or nuclear marker (each)

88187-Flow cytometry interpretation, 2 to 8 Markers (added as FCINT)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PCPRO Plasma Cell Proliferation, Marrow 93363-0

 

Result ID Test Result Name Result LOINC Value
CK056 Monotypic Plasma Cells: 93362-2
CK057 Monotypic PC per Total Events 93021-4
CK058 Monotypic Plasma Cells S-phase 93361-4
CK059 Monotypic Plasma Cells DNA Index 93360-6
CK060 Monotypic Plasma Cells DNA Ploidy 93359-8
CK061 Polytypic PC per Total Events 93358-0
CK062 Polytypic PC per All Plasma Cells 93020-6
CK063 Final Diagnosis 50398-7

Forms

If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request (T726) with the specimen.