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HelpTest Code LAB5566 Insulin-Like Growth Factor-1, Mass Spectrometry, Serum
Useful For
Evaluation of growth disorders
Evaluation of growth hormone deficiency or excess in children and adults
Monitoring of recombinant human growth hormone treatment
Follow-up of individuals with acromegaly and gigantism
Disease States
- Acromegaly
- Gigantism
- Growth hormone deficiency
Reporting Name
IGF-1, LC/MS, SSpecimen Type
SerumNecessary Information
Indicate patient's age and sex.
Specimen Required
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Frozen (preferred) | 28 days | |
| Ambient | 72 hours | ||
| Refrigerated | 72 hours |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
Males:
0-11 months: 18-156 ng/mL
1 year: 14-203 ng/mL
2 years: 16-222 ng/mL
3 years: 22-229 ng/mL
4 years: 30-236 ng/mL
5 years: 39-250 ng/mL
6 years: 47-275 ng/mL
7 years: 54-312 ng/mL
8 years: 61-356 ng/mL
9 years: 67-405 ng/mL
10 years: 73-456 ng/mL
11 years: 79-506 ng/mL
12 years: 84-551 ng/mL
13 years: 90-589 ng/mL
14 years: 95-618 ng/mL
15 years: 99-633 ng/mL
16 years: 104-633 ng/mL
17 years: 107-615 ng/mL
18-22 years: 91-442 ng/mL
23-25 years: 66-346 ng/mL
26-30 years: 60-329 ng/mL
31-35 years: 54-310 ng/mL
36-40 years: 48-292 ng/mL
41-45 years: 44-275 ng/mL
46-50 years: 40-259 ng/mL
51-55 years: 37-245 ng/mL
56-60 years: 34-232 ng/mL
61-65 years: 33-220 ng/mL
66-70 years: 32-209 ng/mL
71-75 years: 32-200 ng/mL
76-80 years: 33-192 ng/mL
81-85 years: 33-185 ng/mL
86-90 years: 33-179 ng/mL
≥91 years: 32-173 ng/mL
Females:
0-11 months: 14-192 ng/mL
1 year: 23-243 ng/mL
2 years: 28-256 ng/mL
3 years: 31-249 ng/mL
4 years: 33-237 ng/mL
5 years: 36-234 ng/mL
6 years: 39-246 ng/mL
7 years: 44-279 ng/mL
8 years: 51-334 ng/mL
9 years: 61-408 ng/mL
10 years: 73-495 ng/mL
11 years: 88-585 ng/mL
12 years: 104-665 ng/mL
13 years: 120-719 ng/mL
14 years: 136-729 ng/mL
15 years: 147-691 ng/mL
16 years: 153-611 ng/mL
17 years: 149-509 ng/mL
18-22 years: 85-370 ng/mL
23-25 years: 73-320 ng/mL
26-30 years: 66-303 ng/mL
31-35 years: 59-279 ng/mL
36-40 years: 54-258 ng/mL
41-45 years: 49-240 ng/mL
46-50 years: 44-227 ng/mL
51-55 years: 40-217 ng/mL
56-60 years: 37-208 ng/mL
61-65 years: 35-201 ng/mL
66-70 years: 34-194 ng/mL
71-75 years: 34-187 ng/mL
76-80 years: 34-182 ng/mL
81-85 years: 34-177 ng/mL
86-90 years: 33-175 ng/mL
≥91 years: 25-179 ng/mL
Tanner Stage reference ranges:
Males
Stage I: 81-255 ng/mL
Stage II: 106-432 ng/mL
Stage III: 245-511 ng/mL
Stage IV: 223-578 ng/mL
Stage V: 227-518 ng/mL
Females
Stage I: 86-323 ng/mL
Stage II: 118-451 ng/mL
Stage III: 258-529 ng/mL
Stage IV: 224-586 ng/mL
Stage V: 188-512 ng/mL
Tanner Stage reference source: Bindlingmaier M, Friedrich N, Emeny RT,et al. Reference intervals for insulin-like growth factor-1 (igf-i) from birth to senescence: results from a multicenter study using a new automated chemiluminescence IGF-I immunoassay conforming to recent international recommendations. J Clin Endocrinol Metab. 2014;99(5):1712-1721
Note: Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for boys at a median age of 11.5 (±2) years and for girls at a median age of 10.5 (±2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African American girls. For boys, there is no definite proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (young adult) should be reached by age 18.
Supportive Data
The IDS automated immunoassay showed a consistent 10% to 20% high bias in comparison to the mass spectrometry assay for insulin-growth factor 1. New reference ranges were calculated for the mass spectrometry assay using 7,325 specimens, including 224 Tanner-staged pediatric samples.
Day(s) Performed
Monday through Sunday
Results reported: Monday through Friday
Report Available
3 to 6 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
84305
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| IGFMS | IGF-1, LC/MS, S | 2484-4 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 62750 | IGF-1, LC/MS, S | 2484-4 |
| 35781 | Z-score | 73561-3 |
Specimen Retention Time
3 monthsForms
If not ordering electronically, complete, print, and send a General Request (T239) with the specimen.