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HelpTest Code LAB5118 Metanephrines, Fractionated, Free, Plasma
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Reporting Name
Metanephrines, Fract., Free, PSpecimen Type
Plasma EDTASpecimen Required
Patient Preparation: Use of an Epi-pen within the last 7 days may produce inaccurate results.
Collection Container/Tube: Lavender top (EDTA)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot plasma into a plastic vial within 2 hours of collection.
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | OK |
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Plasma EDTA | Frozen (preferred) | 28 days | |
| Refrigerated | 14 days | ||
| Ambient | 7 days |
Specimen Minimum Volume
0.3 mL
Day(s) Performed
Monday through Saturday
Specimen Retention Time
2 weeksReport Available
2 to 5 daysReference Values
METANEPHRINE, FREE
<0.50 nmol/L
NORMETANEPHRINE, FREE
<0.90 nmol/L
Useful For
Screening test for presumptive diagnosis of catecholamine-secreting pheochromocytomas or paragangliomas
CPT Code Information
83835
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| PMET | Metanephrines, Fract., Free, P | 57772-6 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 10140 | Normetanephrine, Free | 40851-8 |
| 10139 | Metanephrine, Free | 49700-8 |
Supportive Data
This liquid chromatography tandem mass spectrometry (LC-MS/MS) method replaces the in-house high-performance liquid chromatography with electrochemical detection (HPLC-EC) method. The HPLC-EC method was labor intensive, with a complicated extraction and lengthy run time, and was prone to interferences. The LC-MS/MS method correlates well with Mayo Clinic Laboratories previously performed HPLC-EC method: N=92, slope=0.87, intercept=0.05, r(2)=0.95. The reference ranges remain the same as the HPLC-EC method and were validated by method comparison between these methods. LC-MS/MS also correlates with the National Institutes of Health's HPLC-EC method.
Forms
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-General Request (T239)
-Oncology Test Request (T729)