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HelpTest Code LAB2163 Thyrotropin Receptor Antibody, Serum
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Reporting Name
Thyrotropin Receptor Ab, SSpecimen Type
SerumSpecimen Required
Patient Preparation:
1. For 12 hours before specimen collection do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.
2. Patient should not be receiving heparin treatment.
Collection Container/Tube:
Preferred:Â Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | Reject |
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 7 days | |
| Frozen | 90 days |
Specimen Minimum Volume
0.75 mL
Day(s) Performed
Monday through Saturday
Specimen Retention Time
2 weeksReport Available
1 to 3 daysReference Values
≤1.75 IU/L
Useful For
Recommended first-line test for detection of thyrotropin receptor antibodies
The following situations:
-Differential diagnosis of etiology of thyrotoxicosis in patients with ambiguous clinical findings and/or contraindicated (eg, pregnant or breast-feeding) or nondiagnostic thyroid radioisotope scans
-Diagnosing clinically suspected Graves disease (GD) (eg, extrathyroidal manifestation of GD include endocrine exophthalmos, pretibial myxedema, thyroid acropachy) in patients with normal thyroid function tests
-Determining the risk of neonatal thyrotoxicosis in a fetus of a pregnant female with active or past active GD
-Differential diagnosis of gestational thyrotoxicosis versus first trimester manifestation or recurrence of GD
-Assessing the risk of GD relapse after antithyroid drug treatment
CPT Code Information
83520
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| THYRO | Thyrotropin Receptor Ab, S | 5385-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| THYRO | Thyrotropin Receptor Ab, S | 5385-0 |
Supportive Data
A Mayo method comparison study between this assay and the Kronus TSH Receptor Antibody binding inhibition assay showed an overall agreement between the assays of 96.5% and a calculated Kappa statistic of 0.93.
Forms
If not ordering electronically, complete, print, and send a General Request (T239) with the specimen.