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HelpTest Code LAB1234679 BCR/ABL1, Qualitative, Diagnostic Assay, Varies
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Reporting Name
BCR/ABL1, RNA-Qual, DiagnosticSpecimen Type
VariesOrdering Guidance
This test is only qualitative and should not be used for routine monitoring (ie, quantitative messenger RNA [mRNA] level).
Monitoring of most patients with chronic myeloid leukemia should be performed using BCRAB / BCR/ABL1, p210, mRNA Detection, Reverse Transcription-PCR (RT-PCR), Quantitative, Monitoring Chronic Myelogenous Leukemia (CML), Varies.
Monitoring of patients known to carry a p190 fusion should be performed using BA190 / BCR/ABL1, p190, mRNA Detection, Reverse Transcription-PCR (RT-PCR), Quantitative, Monitoring Assay, Varies.
Additional testing options are available. For ordering guidance see BCR/ABL1 Ordering Guide for Blood and Bone Marrow
Shipping Instructions
1. Refrigerate specimens must arrive within 5 days of collection, and ambient specimens must arrive with 3 days of collection.
2. Collect and package specimens as close to shipping time as possible.
Necessary Information
Pertinent clinical history including if the patient has a diagnosis of chronic myelogenous leukemia or other BCR::ABL1-positive neoplasm is required.
Specimen Required
Submit only 1 of the following specimens:
Specimen Type: Whole blood
Container/Tube:
Preferred: Lavender top (EDTA)
Acceptable: Yellow top (ACD)
Specimen Volume: 10 mL
Collection Instructions:
1. Invert several times to mix blood.
2. Send whole blood specimen in original tube. Do not aliquot.
3. Label specimen as blood.
Specimen Type: Bone marrow
Container/Tube:
Preferred: Lavender top (EDTA)
Acceptable: Yellow top (ACD)
Specimen Volume: 4 mL
Collection Instructions:
1. Invert several times to mix bone marrow.
2. Send bone marrow specimen in original tube. Do not aliquot.
3. Label specimen as bone marrow.
Reject Due To
| Gross hemolysis | Reject |
| Moderately to severely clotted | Reject |
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Varies | Refrigerated (preferred) | 5 days | PURPLE OR PINK TOP/EDTA |
| Ambient | 72 hours | PURPLE OR PINK TOP/EDTA |
Specimen Minimum Volume
Peripheral blood: 8 mL; Bone marrow: 2 mL
Special Instructions
Day(s) Performed
Monday through Saturday
Specimen Retention Time
Blood, bone marrow: 2 weeks; Extracted RNA: 3 monthsReport Available
5 to 10 daysReference Values
A qualitative result is provided that indicates the presence or absence of BCR::ABL1 messenger RNA. When positive, the fusion variant is also reported.
Useful For
Diagnostic workup of patients with a high probability of BCR::ABL1-positive hematopoietic neoplasms, predominantly chronic myeloid leukemia and acute lymphoblastic leukemia
Testing Algorithm
For more information see:
-Myeloproliferative Neoplasm: A Diagnostic Approach to Bone Marrow Evaluation
-Myeloproliferative Neoplasm: A Diagnostic Approach to Peripheral Blood Evaluation
CPT Code Information
81206
81207
81208
81479 (if appropriate for government payers)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| BADX | BCR/ABL1, RNA-Qual, Diagnostic | 55135-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 39466 | Diagnostic BCR/ABL1 Result | No LOINC Needed |
| MP001 | Specimen Type | 31208-2 |
| 19783 | Interpretation | 69047-9 |
Forms
1. Hematopathology Patient Information (T676)
2. If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request (T726) with the specimen.