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HelpTest Code LAB1232026 Cryptococcus Antigen Screen with Titer, Spinal Fluid
Useful For
Aiding in the diagnosis of cryptococcosis
This test should not be performed as a screening procedure for the general population.
This test should not be used as a test of cure or to guide treatment decisions.
Disease States
- Cryptococcosis
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| CLFAT | Cryptococcus Ag Titer, LFA, CSF | Yes | No |
Testing Algorithm
If result is positive, Cryptococcus titer will be performed at an additional charge.
For more information see Meningitis/Encephalitis Panel Algorithm
Reporting Name
Cryptococcus Ag Screen w/Titer, CSFSpecimen Type
CSFSpecimen Required
Container/Tube: Sterile vial
Specimen Volume: 1 mL
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| CSF | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days |
Reject Due To
| Gross hemolysis | Reject |
Reference Values
Negative
Reference values apply to all ages.
Supportive Data
Cerebrospinal fluid (CSF) retrospective specimens (111) were tested in a blinded fashion by the IMMY Cryptococcus Antigen Lateral Flow Assay (LFA) and the Meridian Latex Agglutination (Meridian Bioscience Inc) assay within a 24-hour period. Of these 111 specimens, 45 were also tested by the Meridian Cryptococcus Antigen enzyme immunoassay (EIA) also within a 24-hour period. Samples with discordant results after initial testing were repeated by both assays during the same freeze/thaw cycle. The results are summarized below in Table 1 and Table 2:
Table 1. Comparison of the IMMY LFA to the Meridian latex agglutination assay in CSF
|
Meridian latex agglutination |
||||
|
LFA IMMY |
Positive |
Negative |
Total |
|
|
Positive |
18 |
0 |
18 |
|
|
Negative |
0 |
93 |
93 |
|
|
Total |
18 |
93 |
111 |
|
Sensitivity: 100% (18/18); 95% CI: 81.2%-100%
Specificity: 100% (93/93); 95% CI: 96.0%-100%
Overall Percent Agreement: 100% (111/111); 95% CI: 99.0%-100%
Table 2. Comparison of the IMMY LFA to the Meridian Cryptococcus antigen EIA in CSF
|
Meridian EIA |
||||
|
LFA IMMY |
|
Positive |
Negative |
Total |
|
Positive |
12 |
0 |
12 |
|
|
Negative |
0 |
33 |
33 |
|
|
Total |
12 |
33 |
45 |
|
Sensitivity: 100% (12/12); 95% CI: 72.2%-100%
Specificity: 100% (33/33); 95% CI: 87.8%-100%
Day(s) Performed
Monday through Sunday
Report Available
Same day/1 to 2 daysSpecimen Retention Time
14 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
87899-Cryptococcus screen
87899-Cryptococcus titer (if appropriate)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CLFA | Cryptococcus Ag Screen w/Titer, CSF | 29896-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 62074 | Cryptococcus Ag Screen w/Titer, CSF | 29896-8 |
Forms
If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.