Home
HelpTest Code LAB1232025 Cortisol, Saliva
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Reporting Name
Cortisol, SalivaSpecimen Type
SalivaNecessary Information
Collection time is required.
Specimen Required
If multiple specimens are collected, submit each Salivette under a separate order number.
Patient Preparation:
1. Patient should not brush teeth, eat, drink, or take any oral medication for at least 60 minutes before specimen collection.
2. Have patient rinse mouth thoroughly with water for 1-5 seconds. Wait 10 minutes before collecting the specimen to avoid contamination of the saliva by interfering substance.
Supplies: Cortisol, Saliva Collection Kit (T514)
Container/Tube: Sarstedt Salivette
Specimen Volume: 1.5 mL
Collection Instructions:
1. Provide patient with a Saliva Collection Kit (Salivette) containing the Cortisol - Saliva Collection Instructions and ask them to follow the instructions as written.
2. Instruct patient to collect specimen between 11 p.m. and midnight and record collection time on the Cortisol - Saliva Collection Instructions sheet.
3. Instruct patient to return Cortisol - Saliva Collection Instructions with the appropriately labeled Salivette to the laboratory.
Additional Information: Reference values are also available for an 8 a.m. (7 a.m.-9 a.m.) or a 4 p.m. (3 p.m.-5 p.m.) collection, however, the 11 p.m. to midnight collection is preferred.
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Saliva | Refrigerated (preferred) | 28 days |
| Frozen | 60 days | |
| Ambient | 28 days |
Specimen Minimum Volume
0.6 mL
Special Instructions
Day(s) Performed
Monday through Friday
Specimen Retention Time
2 weeksReport Available
3 to 6 daysReference Values
7 a.m.-9 a.m.: 100-750 ng/dL
3 p.m.-5 p.m.: <401 ng/dL
11 p.m.-midnight: <100 ng/dL
Useful For
Screening for Cushing syndrome
Diagnosis of Cushing syndrome in patients presenting with symptoms or signs suggestive of the disease
CPT Code Information
82533
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| SALCT | Cortisol, Saliva | 2142-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 84225 | Cortisol, Saliva | 2142-8 |
| 23612 | AM Cortisol | 58674-3 |
| 23613 | PM Cortisol | 58668-5 |
| 23614 | Midnight Cortisol | 58642-0 |
Supportive Data
Using this assay, it was determined that late-night salivary cortisol is in the range of 100 ng/mL to 6000 ng/dL (2.76-166 nmol/L) for clinically confirmed Cushing patients (N=11).
Normal values are based on 36 donors (ages 0-8 years), 46 donors (ages 9-17 years), and 102 donors (age >17 years).
Forms
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-General Request (T239)
-Renal Diagnostics Test Request (T830)