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HelpTest Code KCSFP Immunoglobulin Kappa Free Light Chain, Spinal Fluid
Ordering Guidance
For evaluation of multiple sclerosis, the following are available:
-SFIG / Cerebrospinal Fluid IgG Index Profile, Serum and Spinal Fluid
-OLIG / Oligoclonal Banding, Serum and Spinal Fluid
Specimen Required
Only orderable as part of a profile. For more information see MSP3 / Multiple Sclerosis (MS) Profile, Serum and Spinal Fluid.
Specimen Type: Spinal fluid
Container/Tube: Sterile vial
Specimen Volume: 1 mL
Collection Instructions: Label specimen as spinal fluid.
Useful For
Diagnosis of multiple sclerosis and other demyelinating conditions
Reporting Name
Kappa Free Light Chain, CSFSpecimen Type
CSFSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| CSF | Frozen (preferred) | 28 days | |
| Refrigerated | 72 hours | ||
| Ambient | 24 hours |
Reject Due To
| Gross hemolysis | Reject |
| Gross icterus | OK |
Reference Values
Only orderable as part of a profile. For more information see MSP3 / Multiple Sclerosis (MS) Profile, Serum and Spinal Fluid.
Medical decision point: 0.1000 mg/dL
Supportive Data
The McDonald revised criteria states that diagnosis of demyelinating disease can be assumed when 2 unique bands are found in cerebrospinal fluid (CSF) using the oligoclonal banding (OLIG) test.(1)
Based on a published Mayo Clinic study with 325 subjects, this test alone demonstrates comparable performance to OLIG along with increased sensitivity for demyelinating diseases.(2) Replacing an OLIG test with this test would alleviate the need for serum and CSF IgG and albumin, and calculated conversions.
After this initial study, a second larger cohort was used to validate kappa free light chain (FLC) results with a larger number of samples.(3) This study found that in comparison to the current standards of detecting 2 unique CSF bands, kappa FLC results at a value greater than or equal to 0.1000 mg/dL showed comparable sensitivity and specificity to OLIG to support diagnosis of MS. Kappa FLC offers a standardized quantitative measure with a single CSF sample without the need of paired serum, with comparable sensitivity and specificity.
Using MSP3 and the reflex approach, Mayo Clinic studies with over 1300 subjects report 75.5% sensitivity and 86% specificity to identify demyelinating disease from non-demyelinating disease.
Day(s) Performed
Monday through Friday
Report Available
1 to 3 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
83521
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| KCSFP | Kappa Free Light Chain, CSF | 48774-4 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| KCSFP | Kappa Free Light Chain, CSF | 48774-4 |