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Test Code FGAGM Ganglioside (Asialo-GM1, GM1, GM2, GD1a, GD1b, and GQ1b) Antibodies

Reporting Name

Ganglioside Antibodies, IgG-IgM

Specimen Type

Serum SST


Specimen Required


Draw blood in a serum gel tube(s). Spin down and send 1 mL of serum refrigerated in a plastic vial.


Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum SST Refrigerated (preferred) 14 days
  Frozen  365 days

Reject Due To

Hemolysis

Mild OK; Grossly Reject

Thawing

Warm reject; Cold Ok

Lipemia

Mild OK; Grossly Reject

Icterus

Mild OK; Grossly Reject

Other

Plasma, CSF, or other body fluids. Contaminated, heat-inactivated specimens

Reference Values

29 IV or less:                 Negative

30 – 50 IV:                    Equivocal

51 – 100 IV:                   Positive

101 IV or greater:           Strong Positive

 

Interpretation

Ganglioside antibodies are associated with diverse peripheral neuropathies.  Elevated antibody levels to ganglioside-monosialic acid (GM1) and the neutral glycolipid, asialo-GM1 are associated with motor or sensorimotor neuropathies, particularly multifocal motor neuropathy.  Anti-GM1 may occur as IgM (polyclonal or monoclonal) or IgG antibodies.  These antibodies may also be found in patients with diverse connective tissue diseases as well as normal individuals. GD1a antibodies are associated with different variants of Guillain-Barre syndrome (GBS) particularly acute motor axonal neuropathy while GD1b antibodies are predominantly found in sensory ataxic neuropathy syndrome. Anti-GQ1b antibodies are seen in more than 80 percent of patients with Miller-Fisher syndrome and may be elevated in GBS patients with ophthalmoplegia. The role of isolated anti-GM2 antibodies is unknown. These tests by themselves are not diagnostic and should be used in conjunction with other clinical parameters to confirm disease.

Day(s) and Time(s) Performed

Monday, Wednesday, Friday

Analytic Time

1 - 4 days

Performing Laboratory

ARUP Laboratories

Test Classification

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

CPT Code Information

83516 x 6

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FGAGM Ganglioside Antibodies, IgG-IgM 82455-7

 

Result ID Test Result Name Result LOINC Value
Z4245 Asialo-GM1 Antibodies, IgG-IgM 44737-5
Z4246 GM1 Antibodies, IgG-IgM 31500-2
Z4247 GM2 Antibodies, IgG-IgM In Process
Z4248 GD1a Antibodies, IgG-IgM 48656-3
Z4249 GD1b Antibodies, IgG-IgM 26870-6
Z4250 GQ1b Antibodies, IgG-IgM 31674-5

Method Name

Semi –Quantitative Enzyme-Linked Immunosorbent Assay