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HelpTest Code FBILM Biliary Tract Malignancy-Cytology, FISH, Varies
Specimen Required
Supplies:
PreservCyt Vial (T536)
CytoLyt Solution (T564)
Specimen Type: Bile duct brushing, bile duct aspirate, hepatobiliary brushing, or hepatobiliary aspirate
Container/Tube: Separate ThinPrep vial containing 20 mL PreservCyt or CytoLyt solution for each specimen
Specimen Volume: Entire collection
Collection Instructions: Label with site specimen was collected from (eg, right hepatic duct or common bile duct).
Useful For
Assessing bile duct brushing or hepatobiliary brushing specimens for bile tract malignancy
Additional Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| BILMA | Biliary Tract Malignancy, FISH | No | Yes |
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| BILMB | Biliary Tract Malignancy, FISH | No | No |
| BILMC | Biliary Tract Malignancy, FISH | No | No |
| BILMD | Biliary Tract Malignancy, FISH | No | No |
| BILME | Biliary Tract Malignancy, FISH | No | No |
| BILMF | Biliary Tract Malignancy, FISH | No | No |
Testing Algorithm
When this test is ordered, fluorescence in situ hybridization testing will be performed. When additional specimens are received, the laboratory will add BILMA to the first specimen, BILMB to the second specimen, BILMC to the third specimen, and so on.
Reporting Name
Biliary Tract Malignancy-Cyto/FISHSpecimen Type
VariesSpecimen Minimum Volume
See Specimen Required
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Varies | Refrigerated (preferred) | |
| Ambient | ||
Reject Due To
| Pancreatic mass Pancreatic cyst Pancreatic fine-needle aspiration (FNA) |
Reject |
Reference Values
Negative for malignancy.
Supportive Data
Cell counts using the biliary FISH probe set on pancreatobiliary brushings were compared between 49 patients with malignancy and 41 patients without malignancy to determine normal value cutoffs for this assay. The cutoff values were independently validated in a blinded study from brushing samples collected from 112 patients at the time of endoscopic retrograde cholangiopancreatography (ERCP). Among patients with malignancy on follow-up, the sensitivity of a polysomy FISH result was significantly superior to cytology (74% vs. 28%, P<0.001). The specificity of FISH and cytology were similar (96% vs. 100%).
Day(s) Performed
Monday through Friday
Report Available
7 to 10 daysSpecimen Retention Time
Up to 1 week depending on the resultsPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
88112
88377 (if appropriate)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| FBILM | Biliary Tract Malignancy-Cyto/FISH | 95230-9 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 71291 | Interpretation | 69965-2 |
| 71292 | Participated in the Interpretation | No LOINC Needed |
| 71293 | Report electronically signed by | 19139-5 |
| 71294 | Addendum | 35265-8 |
| 71295 | Gross Description | 22634-0 |
| CY070 | Collection Procedure | 33724-6 |
| CY042 | Source | 22633-2 |
| CY043 | Clinical History | 22636-5 |
| CY044 | Fixative | 8100-0 |
| 71570 | Disclaimer | 62364-5 |
| 71816 | Case Number | 80398-1 |