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HelpTest Code EGFRS EGFR Gene, Targeted Mutation Analysis, 51 Mutation Panel, Tumor
Necessary Information
Pathology report must accompany specimen for testing to be performed.
Specimen Required
Submit only 1 of the following specimens:
Preferred:
Specimen Type: Tissue, smear stained with Diff Quik, fine needle aspirate (FNA), or pleural fluid in cell blocks
Container/Tube: Tissue block
Collection Instructions: Submit a formalin-fixed, paraffin-embedded (FFPE) tissue block.
Acceptable:
Specimen Type: Tissue, smear stained with Diff Quik, FNA, or pleural fluid in cell block or cytology blood smear
Container/Tube: Slides
Specimen Volume: 1 Hematoxylin and eosin stained and 5 unstained
Collection Instructions:
1. For FFPE tissue, FNA or pleural fluid: Submit 1 slide stained with hematoxylin and eosin and 5 unstained, non-baked slides with 5 to 10-micron thick sections of the tumor tissue.
2. For cytology blood smear: Submit up to 2 slides stained with Diff Quik
Useful For
Identifying non-small cell lung cancers that may respond to epidermal growth factor receptor-targeted therapies
Additional Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| SLIRV | Slide Review in MG | No, (Bill Only) | Yes |
Testing Algorithm
When this test is ordered, slide review will always be performed at an additional charge.
Reporting Name
EGFR Gene, Mutation Analysis, TumorSpecimen Type
VariesSpecimen Minimum Volume
Formalin-fixed, paraffin-embedded tissue block or Slides: see Specimen Required
Cytology smear stained with Diff Quik: >1000 cells
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Varies | Ambient (preferred) | ||
| Refrigerated | |||
Reject Due To
| Specimens that have been decalcified (all methods) | Reject |
Reference Values
An interpretive report will be provided.
Day(s) Performed
Monday through Friday
Report Available
4 to 7 daysSpecimen Retention Time
Unused portions of blocks will be returned. Unused slides are stored indefinitely.Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
81235-EGFR (epidermal growth factor receptor) (eg, non-small cell lung cancer) gene analysis, common variants (eg, exon 19 LREA deletion, L858R, T790M, G719A, G719S, L861Q)
88381-Microdissection, manual
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| EGFRS | EGFR Gene, Mutation Analysis, Tumor | 21665-5 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 616123 | Result Summary | 50397-9 |
| 616124 | Result | 21665-5 |
| 616125 | Interpretation | 69047-9 |
| 616126 | Specimen | 31208-2 |
| 616127 | Source | 31208-2 |
| 616128 | Tissue ID | 80398-1 |
| 616129 | Released By | 18771-6 |
Disease States
- Non-small cell lung cancer
Forms
If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.