Sign in →

Test Code CRMWC Collapsin Response-Mediator Protein-5-IgG, Western Blot, Spinal Fluid

Test Down Notes

Effective October 23, 2025, this test is currently unavailable due to limited clinical utility for this method. It is recommended to order a phenotype-specific autoimmune/paraneoplastic evaluation. For more information as well as phenotype-specific testing options, see Autoimmune Neurology Test Ordering Guide.

Useful For

Evaluation of cases of chorea, vision loss, cranial neuropathy and myelopathy

Reporting Name

CRMP-5-IgG Western Blot, CSF

Specimen Type

CSF


Ordering Guidance


It is recommended an evaluation be ordered in conjunction with this testing if not previously performed. Multiple neurological phenotype-specific autoimmune/paraneoplastic evaluations are available. For more information as well as phenotype-specific testing options, see Autoimmune Neurology Test Ordering Guide.



Shipping Instructions


Send specimen refrigerated.



Necessary Information


Provide the following information:

-Relevant clinical information

-Ordering healthcare professional name, phone number, mailing address, and e-mail address



Specimen Required


Container/Tube: Sterile vial

Specimen Volume: 3 mL


Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type Temperature Time
CSF Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Reference Values

Negative

Supportive Data

In the Neuroimmunology Laboratory's current clinical service activity, the frequency of collapsin response-mediator protein-5 (CRMP-5)-IgG detection is approximately 2 per 1,000 sera tested, approximating that of the Purkinje cell cytoplasmic autoantibody-type 1 (PCA-1, or "anti-Yo"). A lung carcinoma was found in 77% of 116 patients, mostly limited small cell type; 6% had thymoma and 7% had miscellaneous neoplasms.

Day(s) Performed

Monday through Thursday

Report Available

5 to 10 days

Specimen Retention Time

28 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

84182

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CRMWC CRMP-5-IgG Western Blot, CSF 53707-6

 

Result ID Test Result Name Result LOINC Value
21747 CRMP-5-IgG Western Blot, CSF 53707-6