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Test Code BILAO Biliary Tract Malignancy, FISH, Varies


Specimen Required


Supplies: PreservCyt Vial (T536)

Specimen Type: Bile duct brushing, bile duct aspirate, hepatobiliary brushing, or hepatobiliary aspirate (fine-needle aspiration is not acceptable)

Container/Tube: Separate ThinPrep vial, containing 20 mL PreservCyt or CytoLyt solution for each specimen

Specimen Volume: Entire collection

Collection Instructions:

1. If performing local cytology in addition to fluorescence in situ hybridization testing, aliquot half of the specimen into another ThinPrep vial before processing the specimen.

2. Submission of residual specimen (after processing other testing) may compromise the sensitivity of the test.

3. Label each specimen with specific source (eg, right hepatic duct or common bile duct).


Useful For

Assessing bile duct brushing or hepatobiliary brushing specimens for biliary tract malignancy

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
BILOB Biliary Tract Malignancy, FISH No No
BILOC Biliary Tract Malignancy, FISH No No
BILOD Biliary Tract Malignancy, FISH No No
BILOE Biliary Tract Malignancy, FISH No No
BILOF Biliary Tract Malignancy, FISH No No

Testing Algorithm

When this test is ordered, fluorescence in situ hybridization testing will be performed. When additional specimens are received, the laboratory will add BILOB to the second specimen, BILOC to the third specimen, and so on.

Special Instructions

Reporting Name

Biliary Tract Malignancy, FISH

Specimen Type

Varies

Specimen Minimum Volume

See Specimen Required

Specimen Stability Information

Specimen Type Temperature Time
Varies Refrigerated (preferred)
  Ambient 

Reject Due To

Pancreatic mass
Pancreatic cyst
Pancreatic fine-needle aspiration (FNA)  		 Reject

Reference Values

No abnormality detected by fluorescence in situ hybridization

Supportive Data

Cell counts using the biliary fluorescence in situ hybridization (FISH) probe set on pancreatobiliary brushings were compared between 49 patients with malignancy and 41 patients without malignancy to determine normal value cutoffs for this assay. The cutoff values were independently validated in a blinded study from brushing samples collected from 112 patients at the time of endoscopic retrograde cholangiopancreatography. Among patients with malignancy on follow-up, the sensitivity of a polysomy FISH result was significantly superior to cytology (74% vs. 28%, P<0.001). The specificity of FISH and cytology were similar (96% vs. 100%).

Day(s) Performed

Monday through Friday

Report Available

7 to 10 days

Specimen Retention Time

Until reported

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

88377

LOINC Code Information

Test ID Test Order Name Order LOINC Value
BILAO Biliary Tract Malignancy, FISH 95229-1

 

Result ID Test Result Name Result LOINC Value
71918 Result Summary 50397-9
71919 Result 95229-1
71920 Interpretation 69965-2
71921 Reason for Referral 42349-1
71922 Specimen 31208-2
MC029 Source 39111-0
MC030 Fixation 8100-0
MC031 Collection Method 33724-6
MC032 Clinical History 22636-5
71927 Method 85069-3
71928 Released By 18771-6