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HelpTest Code lab1231751 Leukocyte Adhesion Deficiency Type 1, CD11a/CD18 and CD11b/CD18 Complex Immunophenotyping, Blood
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Reporting Name
Leukocyte Adhesion Def. Type 1, BSpecimen Type
Whole Blood EDTAShipping Instructions
Testing is performed Monday through Friday. Specimens not received by 4 p.m. (CST) on Friday may be canceled.
Draw and package specimen as close to shipping time as possible. It is recommended that specimens arrive within 24 hours of draw.
Specimens arriving on the weekend and observed holidays may be canceled.
Necessary Information
Date and time of collection and healthcare professional name and phone number are required.
Specimen Required
Container/Tube: Lavender top (EDTA)
Specimen Volume: 5 mL
Collection Instructions: Send whole blood specimen in original tube. Do not aliquot.
Additional Information: For serial monitoring, it is recommended that specimens are collected at the same time of day.
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Whole Blood EDTA | Ambient | 72 hours | PURPLE OR PINK TOP/EDTA |
Specimen Minimum Volume
2 mL
Day(s) Performed
Monday through Friday
Specimen Retention Time
4 daysReport Available
3 to 4 daysReference Values
Normal (reported as normal or absent expression for each marker)
Useful For
Aiding in the diagnosis of leukocyte adhesion deficiency syndrome type 1, primarily in patients younger than 18 years
CD11a, CD11b, and CD18 phenotyping
CPT Code Information
86356 x 3
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| LAD1 | Leukocyte Adhesion Def. Type 1, B | 94266-4 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 81155 | Leukocyte Adhesion Deficiency, B | No LOINC Needed |
| 430 | CD11a | 94268-0 |
| 388 | CD11b | 94267-2 |
| 431 | CD18 | 94265-6 |
| 432 | LAD Interpretation | 69052-9 |
Genetics Test Information
ITGB2 is located on the long arm of chromosome 21(21q22.3). It encodes the common beta 2 integrin subunit (CD18), which is necessary for the expression of lymphocyte function-associated antigen 1 (CD11a/CD18), Mac-1/CR3 (CD11b/CD18), and p150/95 (CD11c/CD18).
Variants in this gene are the underlying cause for the autosomal recessive leukocyte adhesion deficiency type 1.