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Test Code VALPR/LAB24 Valproic Acid

Performing Laboratory

Asante Rogue Regional Medical Center / Asante Three Rivers Medical Center

Specimen Requirements


Yellow (Gold) top tube (SST)  

Lithium Heparin Green top tube

Outpatient clients MUST draw SST



Plain Red top tube  No SST or PST


TROUGH levels should be drawn 15 minutes prior to next dose, please provide last dose information

Specimen Transport Temperature and Stability

Centrifuge and refrigerate within 2 hours of collection

Primary tube: Spun SST stable 48 hours at  2° to 8° C

Serum stable 48 hours if aliquoted and refrigerated at 2° to 8° C

Specimen Minimum Volume

0.5 mL

Reasons for Rejection




Quantity not sufficient (QNS)

Lack of Two Patient Identifiers:

         1-Patient's First & Last name 

         2-Patient's Date of Birth

Day(s) Test Set Up

Routine – same day

ASAP – 2 hours after receipt of specimen in lab

STAT – 1 hour after receipt of specimen in lab

Additional Information

Valproic acid (Depakene) is used for the treatment of grand mal epilepsy and petit mal epilepsy in children, often in combination with other anticonvulsant drugs, and may also be prescribed for bipolar disease.  It is rapidly absorbed after oral administration with a peak concentration occurring within 4 hours.  Because of the relatively short half life and rapid absorption, serum concentrations fluctuate markedly.  Very little of the drug is metabolized and most appears in the urine unchanged.  The main side effect is fatigue which may be associated with hypersalivation.


Turbidimetric Inhibition 

Performing Department


Test Classification and CPT Coding

80164  -  Dipropylacetic acid (valproic acid)

Billing Code