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Test Code SMPU Monoclonal Protein Screen, 24 Hour, Urine


Shipping Instructions


Refrigerate specimen during collection and send refrigerated.



Necessary Information


24-Hour volume (in milliliters) is required.



Specimen Required


Supplies: Urine Container, 60 mL (T313)

Submission Container/Tube: Plastic, 60-mL urine bottle

Specimen Volume: 50 mL

Collection Instructions:

1. Collect urine for 24 hours.

2. Aliquot between 30 mL and 50 mL of urine into a plastic, 60-mL urine bottle.

Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens for multiple collections.


Useful For

Monitoring patients with monoclonal gammopathies

Profile Information

Test ID Reporting Name Available Separately Always Performed
MPTU M-protein Mass-Fix, 24 HR, U No Yes
PTU3 Protein, Total, 24 HR, U Yes Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
PEU Protein Electrophoresis, 24 Hr, U No No

Testing Algorithm

Testing for urine monoclonal proteins (M-proteins) with mass-fix alone is not considered adequate screening for monoclonal gammopathies.

 

The laboratory will evaluate the urine for M-proteins using the mass-fix method, and if positive for M-protein, protein electrophoresis will be performed at an additional charge.

 

The following algorithms are available:

-Amyloidosis: Laboratory Approach to Diagnosis

-Multiple Myeloma: Laboratory Screening

Reporting Name

M-protein Screen, 24 HR, U

Specimen Type

Urine

Specimen Minimum Volume

30 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 14 days
  Frozen  5 days
  Ambient  24 hours

Reject Due To

  All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Reference Values

PROTEIN, TOTAL

<229 mg/24 hours

 

Reference values have not been established for patients younger than 18 years of age.

 

ELECTROPHORESIS, PROTEIN

The following fractions, if present, will be reported as mg/24 hours:

Albumin

Alpha-1-globulin

Alpha-2-globulin

Beta-globulin

Gamma-globulin

 

MASS-FIX M-PROTEIN ISOTYPE

M-protein Isotype MS:

No monoclonal protein detected

 

Flag M-protein Isotype MS:

Negative

Day(s) Performed

Monday through Friday

Report Available

4 to 6 days

Specimen Retention Time

See Individual Test IDs

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

84156

84166 Electrophoresis, protein (if appropriate)

0077U

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SMPU M-protein Screen, 24 HR, U In Process

 

Result ID Test Result Name Result LOINC Value
617117 M-protein Isotype MS, 24 HR, U In Process
TP6 Total Protein, 24 HR, U 2889-4
TM24 Collection Duration 13362-9
617118 Flag M-protein Isotype MS, 24 HR, U No LOINC Needed
VL92 Urine Volume 3167-4

Urine Preservative Collection Options

Note: The addition of preservative or application of temperature controls must occur within 4 hours of completion of the collection.

Ambient

OK

Refrigerate

Preferred

Frozen

OK

50% Acetic Acid

No

Boric Acid

No

Diazolidinyl Urea

OK

6M Hydrochloric Acid

No

6M Nitric Acid

No

Sodium Carbonate

No

Thymol

OK

Toluene

No