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HelpTest Code PSYQP Psychotropic Pharmacogenomics Gene Panel, Varies
Necessary Information
Prior Authorization is available, but not required, for this test. If proceeding with the prior authorization process, submit the required form with the specimen.
Specimen Required
Submit only 1 of the following specimens:
Specimen Type: Whole blood
Container/Tube: Lavender top (EDTA)
Specimen Volume: 3 mL
Collection Instructions:
1. Invert several times to mix blood.
2. Send whole blood specimen in original tube. Do not aliquot.
Specimen Stability Information: Ambient (preferred) 9 days/Refrigerated 30 days
Specimen Type: Saliva
Patient Preparation: Patient should not eat, drink, smoke, or chew gum 30 minutes prior to collection.
Supplies: Saliva Swab Collection Kit (T786)
Specimen Volume: 2 Swabs, use 2 kits for collection
Collection Instructions: Collect and send specimen per kit instructions.
Additional Information: Due to lower concentration of DNA yielded from saliva, testing cannot proceed to reflex testing for CYP2D6 sequencing and will stop after initial testing is complete.
Specimen Stability Information: Ambient 30 days
Specimen Type: Extracted DNA
Container/Tube: 2-mL screw top tube
Specimen Volume: 100 mcL (microliters)
Collection Instructions:
1. The preferred volume is 100 mcL at a concentration of 50 ng/mcL.
2. Provide concentration of DNA and volume on tube.
Specimen Stability Information: Frozen (preferred) 1 year/Ambient/Refrigerated
Forms
1. New York Clients-Informed consent is required. Document on the request form or electronic order that a copy is on file. The following documents are available:
-Informed Consent for Genetic Testing (T576)
-Informed Consent for Genetic Testing-Spanish (T826)
2. Psychotropic Pharmacogenomics Gene Panel Prior Authorization Ordering Instructions
3. If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.
Useful For
Individualizing selection and dosage of medications prescribed for treatment of depression and other psychiatric disorders based on genetic variation
Identifying genetic variation in genes known to be associated with response and/or risk of toxicity with psychotropic medications
Evaluating patients who have failed therapy with selective serotonin reuptake inhibitors (SSRI)
Evaluating patients with treatment-resistant depression
Predicting response time to improvement with SSRI
Genetics Test Information
This test includes targeted testing to evaluate the following genes: ANKK1, ADRA2, CHRNA3, COMT, CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, DRD2, EPHX1, GRIK4, HLA-A*31:01, HLA-B*15:02, HTR2A, HTR2C, MTHFR, OPRM1, SCN1A, SLC6A4 (5-HTT), and UGT2B15.
CYP2D6 testing is done in 2 tiers when needed. Tier 1 uses a polymerase chain reaction (PCR)-based 5'-nuclease assay to determine the variants present. All samples also have copy number determined by PCR-based 5'-nuclease assay. Testing in tier 1 allows for the detection of all common CYP2D6 variants (eg, *2, *3, *4, *5, *6, *7, *8, *9, *10, *17, *29, *35, *41, *59) and rarer alleles such as *11, *12, *14, *15, and *114. Duplications and multiplications of alleles are also identified. Unitary and tandem CYP2D7-2D6 (*13) alleles and CYP2D6-2D7 (eg, *4N, *36, and *68) alleles can also be detected. Tier 2 testing involves sequencing using fluorescent dye-terminator chemistry and is only done if an ambiguous phenotype results from tier 1 testing. Approximately 3% of samples require tier 2 testing.
Prior Authorization is available for this assay.
Testing Algorithm
If a specimen requires follow-up for CYP2D6, then reflex testing will be performed as appropriate at an additional charge.
For more information see CYP2D6 Comprehensive Cascade Testing Algorithm.
Special Instructions
Reporting Name
Psychotropic PGx Panel, VSpecimen Type
VariesSpecimen Minimum Volume
Blood: 1 mL
Saliva, extracted DNA: see Specimen Required
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Varies | Varies | ||
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Reference Values
An interpretive report will be provided.
Day(s) Performed
Tuesday
Report Available
3 to 14 daysSpecimen Retention Time
Whole blood/Saliva: 2 weeks; Extracted DNA: 2 monthsPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
81418
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| PSYQP | Psychotropic PGx Panel, V | 94753-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 610209 | ADRA2A rs1800544 Genotype | 94401-7 |
| 610210 | ANKK1 rs1800497 Genotype | 94402-5 |
| 610211 | CHRNA3 rs1051730 Genotype | 94403-3 |
| 610212 | COMT rs4680 Genotype | 74511-7 |
| 610213 | CYP1A2 Genotype | 72884-0 |
| 610214 | CYP1A2 Phenotype | 94254-0 |
| 610215 | CYP2B6 Genotype | 72882-4 |
| 610216 | CYP2B6 Phenotype | 79720-9 |
| 610573 | CYP2B6 Activity Score | 104666-3 |
| 610217 | CYP2C19 Genotype | 57132-3 |
| 610218 | CYP2C19 Phenotype | 79714-2 |
| 610574 | CYP2C19 Activity Score | 104667-1 |
| 610219 | CYP2C9 Genotype | 46724-1 |
| 610220 | CYP2C9 Phenotype | 79716-7 |
| 610575 | CYP2C9 Activity Score | 104668-9 |
| 610221 | CYP2D6 Genotype | 40425-1 |
| 610222 | CYP2D6 Phenotype | 79715-9 |
| 610576 | CYP2D6 Activity Score | 104669-7 |
| 610223 | CYP3A4 Genotype | 81139-8 |
| 610224 | CYP3A4 Phenotype | 81145-5 |
| 610225 | CYP3A5 Genotype | 81140-6 |
| 610226 | CYP3A5 Phenotype | 79717-5 |
| 610227 | DRD2 rs1799978 Genotype | 94411-6 |
| 610228 | EPHX1 rs2234922 Genotype | 94412-4 |
| 610229 | GRIK4 rs1954787 Genotype | 94413-2 |
| 610230 | HLA-A*31:01 Genotype | 79712-6 |
| 610231 | HLA-B*15:02 Genotype | 57979-7 |
| 610232 | HTR2A rs7997012 Genotype | 93190-7 |
| 610233 | HTR2C rs3813929 Genotype | 93191-5 |
| 610234 | HTR2C rs1414334 Genotype | 93192-3 |
| 610235 | MTHFR Genotype | 94414-0 |
| 610236 | OPRM1 rs1799971 Genotype | 94415-7 |
| 610237 | SCN1A rs3812718 Genotype | 94416-5 |
| 610238 | SLC6A4 5HTTLPR Genotype | 94417-3 |
| 610239 | UGT2B15 rs1902023 Genotype | 94418-1 |
| 610240 | Interpretation | 69047-9 |
| 610241 | Additional Information | 48767-8 |
| 610242 | Method | 85069-3 |
| 610243 | Disclaimer | 62364-5 |
| 610244 | Reviewed by | 18771-6 |
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| 2D61Z | CYP2D6 Full Gene Sequence | No, (Bill Only) | No |
| 2D62Z | CYP2D6 GEN CYP2D6-2D7 Hybrid | No, (Bill Only) | No |
| 2D63Z | CYP2D6 GEN CYP2D7-2D6 Hybrid | No, (Bill Only) | No |
| 2D64Z | CYP2D6 Nonduplicated Gene | No, (Bill Only) | No |
| 2D65Z | CYP2D6 5' Gene DUP/MLT | No, (Bill Only) | No |
| 2D66Z | CYP2D6 3' Gene DUP/MLT | No, (Bill Only) | No |
Prior Authorization
Insurance preauthorization is available for this testing; forms are available.
Patient financial assistance may be available to those who qualify. Patients who receive a bill from Mayo Clinic Laboratories will receive information on eligibility and how to apply.