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HelpTest Code PINS Proinsulin, Plasma
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Reporting Name
Proinsulin, PSpecimen Type
Plasma EDTASpecimen Required
Patient Preparation:
Fasting: 8 hours, required; Infants younger than 2 years should fast a maximum of 6 hours
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Ice-cooled, lavender top (EDTA)
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL Plasma
Collection Instructions:
1. Immediately after draw, place the whole blood on ice for at least 10 minutes.
2. Centrifuge at refrigerated temperature, aliquot plasma into a plastic vial, and freeze specimen.
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | OK |
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Plasma EDTA | Frozen | 30 days |
Specimen Minimum Volume
Plasma: 0.25 mL
Day(s) Performed
Tuesday, Friday
Specimen Retention Time
2 weeksReport Available
2 to 5 daysReference Values
3.6-22 pmol/L
Useful For
As part of the diagnostic workup of suspected insulinoma
As part of the diagnostic workup of patients with suspected prohormone convertase 1/3 deficiency
As part of the diagnostic workup of patients with suspected proinsulin variations
CPT Code Information
84206
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| PINS | Proinsulin, P | 27882-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 80908 | Proinsulin, P | 27882-0 |
Method Description
Sequential 2-site electrochemiluminescent immunoassay performed on the MesoScale Discovery instrument. The assay uses a monoclonal biotinylated anti-insulin capture antibody and an anti-C-peptide detection antibody labeled with SULFO-TAG. The signal is directly proportional to the amount of proinsulin in the sample. Assay calibration is traceable to the World Health Organization 1st International Standard for human proinsulin, NIBSC code: 09/296. This assay demonstrates no cross-reactivity with insulin or C-peptide.(Unpublished Mayo method)