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Test Code P1NP Intact Procollagen I N-Terminal, Serum


Specimen Required


Patient Preparation: For 12 hours before specimen collection, patient should not take multivitamins or dietary supplements (eg, hair, skin, and nail supplements) containing biotin (vitamin B7).

Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL Serum

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Useful For

Aiding in monitoring antiresorptive and anabolic therapy in patients with osteoporosis

 

This test should not be used as a screening test for osteoporosis in the general population.

Reporting Name

Intact Procollagen I N-Terminal, S

Specimen Type

Serum

Specimen Minimum Volume

Serum: 0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Frozen  90 days
  Ambient  7 days

Reject Due To

Gross hemolysis Reject
Gross lipemia OK
Gross icterus OK

Reference Values

Adult male: 26-108 ng/mL

Adult female premenopausal: 22-103 ng/mL

Adult female postmenopausal: 18-119 ng/mL

 

Reference values have not been established for patients who are younger than 18 years.

Method Description

The assay is based on chemiluminescence technology. Twenty microliters of patient sample or calibrator are added to a diluent, and a portion incubated with a biotinylated anti-procollagen type I N-terminal propeptide (PINP) monoclonal antibody, an acridinium labelled monoclonal antibody, streptavidin labelled magnetic particles and an assay buffer. The magnetic particles are captured using a magnet, and a wash step is performed to remove any unbound analyte. Trigger reagents are added; the resulting light emitted by the acridinium label is directly proportional to the concentration of intact PINP in the original sample.(Unpublished Mayo method)

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Specimen Retention Time

2 weeks

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

83520

LOINC Code Information

Test ID Test Order Name Order LOINC Value
P1NP Intact Procollagen I N-Terminal, S 77370-5

 

Result ID Test Result Name Result LOINC Value
P1NP Intact Procollagen I N-Terminal, S 77370-5