Additional Information

Concentration of hLH and hFSH in serum are commonly determined in investigations of menstrual cycle, fertility and pubertal developmental abnormalities, such as premature ovarian failure, menopause, ovulatory disorders and pituitary failure.  The ratio of hLH/hFSH has been used to assist in the diagnosis of polycystic ovary disease.  Low concentrations of hLH and hFSH may indicate pituitary failure while elevated concentrations of hLH and hFSH along with decreased concentrations of gonadal steroids may indicate gonadal failure (menopause, ovariectomy, premature ovarian syndrome, Turner’s syndrome).  Low concentrations of gonadotropin are usually observed in females taking oral steroid-based contraceptives.  In the male, elevated hLH and hFSH with low concentrations of gonadal steroids may indicate testicular failure or anorchia.  In Klinefelter’s syndrome, hLH may be elevated due to Sertoli cell failure.