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Test Code LAB746 Thyroid-Stimulating Immunoglobulin, Serum

Important Note

Mayo's test code: TSI

Test Down Notes

This test is temporarily unavailable. For additional details, see test update here.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Reporting Name

Thyroid-Stimulating Immunoglob, S

Specimen Type

Serum


Ordering Guidance


This test is used for second-order testing for autoimmune thyroid disease.

 

For suspected cases of autoimmune hypothyroidism, the first-order testing is TPO / Thyroperoxidase Antibodies, Serum.

 

For suspected cases of autoimmune thyroid disease, first-order testing includes TPO and THYRO / Thyrotropin Receptor Antibody, Serum.



Specimen Required


Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Reject Due To

Gross hemolysis Reject
Gross lipemia OK
Gross icterus OK

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Frozen (preferred) 60 days
  Refrigerated  7 days
  Ambient  24 hours

Specimen Minimum Volume

0.3 mL

Day(s) Performed

Monday through Friday

Specimen Retention Time

3 months

Report Available

2 to 6 days

Reference Values

≤1.3 TSI index

Reference values apply to all ages.

Useful For

Second-order testing for autoimmune thyroid disease, including:

-Differential diagnosis of etiology of thyrotoxicosis in patients with ambiguous clinical signs or contraindicated (eg, pregnant or breast-feeding) or indeterminate thyroid radioisotope scans

-Diagnosis of clinically suspected Graves disease (eg, extrathyroidal manifestations of Graves disease: endocrine exophthalmos, pretibial myxedema, thyroid acropachy) but normal thyroid function tests

-Determining the risk of neonatal thyrotoxicosis in a fetus of a pregnant female with active or past Graves disease

-Differential diagnosis of gestational thyrotoxicosis versus first-trimester manifestation or recurrence of Graves disease

-Assessing the risk of Graves disease relapse after antithyroid drug treatment

 

A combination of TSI / Thyroid-Stimulating Immunoglobulin, Serum and THYRO / Thyrotropin Receptor Antibody, Serum is useful as an adjunct in the diagnosis of unusual cases of hypothyroidism (eg, Hashitoxicosis).

CPT Code Information

84445

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TSI Thyroid-Stimulating Immunoglob, S 30567-2

 

Result ID Test Result Name Result LOINC Value
8634 Thyroid-Stimulating Immunoglob, S 30567-2

Supportive Data

Pediatric data is based on a Mayo study of 50 male and 50 female children between the ages of 10 days and 18 years.

Forms

If not ordering electronically, complete, print, and send a General Request (T239) with the specimen.