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HelpTest Code LAB5101 Imipramine and Desipramine, Serum
Useful For
Monitoring imipramine and desipramine concentrations during therapy
Evaluating potential imipramine and desipramine toxicity
May aid in evaluating patient compliance
Reporting Name
Imipramine and Desipramine, SSpecimen Type
Serum RedSpecimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Red top (Serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL Serum
Collection Instructions:
1. Collect specimen immediately before next scheduled dose (minimum 12 hours after last dose).
2. Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial. Serum must be separated from cells within 2 hours of collection.
Specimen Minimum Volume
Serum: 0.25 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days |
| Frozen | 28 days | |
| Ambient | 7 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
Reference Values
Imipramine and Desipramine
Total therapeutic concentration: 175-300 ng/mL
Desipramine
Therapeutic concentration: 100-300 ng/mL
Note: Therapeutic ranges are for specimens collected at trough (ie, immediately before next scheduled dose). Levels may be elevated in non-trough specimens.
Method Description
The tricyclic antidepressants are extracted from serum using a solvent to precipitate proteins. The supernatant is removed, and analysis is by liquid chromatography tandem mass spectrometry.(Unpublished Mayo method)
Day(s) Performed
Monday, Wednesday, Friday
Report Available
3 to 5 daysSpecimen Retention Time
14 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
80299
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| IMIPR | Imipramine and Desipramine, S | 43123-9 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 63508 | Imipramine | 3690-5 |
| 37121 | Desipramine | 3531-1 |
| 37122 | Imipramine and Desipramine | 9627-1 |
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.