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HelpTest Code LAB131324 Porphyrins, Quantitative, 24 Hour, Urine
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Reporting Name
Porphyrins, QN, USpecimen Type
UrineOrdering Guidance
This 24-hour urine test should be ordered when the specimen will not reach Mayo Clinic Laboratories (MCL) within 72 hours. If the specimen will reach MCL within 72 hours, order PQNRU / Porphyrins, Quantitative, Random, Urine.
Shipping Instructions
Ship specimen in amber container to protect from light.
Necessary Information
1. 24-Hour volume (in milliliters) is required.
2. Patient's sex is required.
3. Collection date and time should be documented upon completion of the 24-hour collection.
4. Include a list of medications the patient is currently taking.
Specimen Required
Patient Preparation: Patient should not consume any alcohol for the 24 hours before, as well as during, specimen collection.
Supplies:
-Urine Container - Amber, 60-mL (T596)
-Sodium Carbonate, 5 gram (T272)
Container/Tube: Amber, 60-mL urine container
Specimen Volume: 20 to 50 mL
Collection Instructions:
1. Add 5 g of sodium carbonate as preservative at start of collection. This preservative is intended to achieve a pH above 7. Do not substitute sodium bicarbonate for sodium carbonate.
2. Collect a 24-hour urine specimen.
3. The container should be refrigerated and protected from light as much as possible during collection.
4. Record volume and duration. An aliquot should be frozen when collection is complete.
Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens for multiple collections.
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Frozen | 7 days | LIGHT PROTECTED |
Specimen Minimum Volume
15 mL
Special Instructions
Day(s) Performed
Monday through Friday
Specimen Retention Time
1 weekReport Available
2 to 4 daysReference Values
Uroporphyrins (Octacarboxyl):
≤30 nmol/24 h
Heptacarboxylporphyrins:
≤9 nmol/24 h
Hexacarboxylporphyrins:
≤8 nmol/24 h
Pentacarboxyporphyrins:
≤10 nmol/24 h
Copropprphyrins (Tetracboxyl)
Males: ≤230 nmol/24 h
Females: ≤168 nmol/24 h
Porphobilinogen:
≤2.2 mcmol/24 h
Useful For
Preferred screening test for congenital erythropoietic porphyria and porphyria cutanea tarda and during symptomatic periods for acute intermittent porphyria, hereditary coproporphyria, and variegate porphyria when specimen transport will be longer than 72 hours
Testing Algorithm
The following algorithms are available:
CPT Code Information
84110-Porphobilinogen, quantitative
84120-Porphyrins, quantitation and fractionation
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| PQNU | Porphyrins, QN, U | 43116-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| TM3 | Collection Duration | 13362-9 |
| VL1 | Urine Volume | 3167-4 |
| 29357 | Uroporphyrin, Octa | 15096-1 |
| 29358 | Heptacarboxylporphyrins | 25434-2 |
| 29359 | Hexacarboxylporphyrins | 25438-3 |
| 29360 | Pentacarboxylporphyrins | 25494-6 |
| 29361 | Coproporphyrin, Tetra | 15041-7 |
| 29362 | Porphobilinogen | 14882-5 |
| 23403 | Interpretation | 59462-2 |
Disease States
- Porphyria
Genetics Test Information
This test is preferred during symptomatic periods for acute intermittent porphyria, hereditary coproporphyria, and variegate porphyria when specimen transport will be longer than 72 hours. If the specimen will be received at Mayo Clinic Laboratories within 72 hours of collection, PQNRU / Porphyrins, Quantitative, Random, Urine is recommended.
Testing includes porphobilinogen, which is useful in the evaluation of the acute porphyrias.
This is the preferred test to begin assessment for congenital erythropoietic porphyria and porphyria cutanea tarda.
Forms
If not ordering electronically, complete, print, and send a Biochemical Genetics Test Request (T798) with the specimen.