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HelpTest Code LAB1235610 Soluble Liver Antigen (SLA) Autoantibody
Reporting Name
SLA AutoantibodySpecimen Type
SerumSpecimen Required
Specimen Required
Specimen Type: Serum
Container/Tube: Red or SST
Specimen Volume: 1mL
Collection Instructions: Draw blood in a plain red-top tube(s), serum gel tube(s) is acceptable. Spin down and send 1 mL of serum refrigerated in a plastic vial.
Specimen Minimum Volume
0.3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 8 days | |
| Frozen | 28 days | ||
| Ambient | 48 hours |
Reject Due To
| Hemolysis | Mild OK; Gross reject |
| Lipemia | Mild OK; Gross reject |
| Icterus | NA |
| Other | Microbially contaminated serum; Heavy visible particulate in specimen |
Reference Values
Reference Range: Negative 0.0-20.0 U
                        Equivocal 20.1-24.9 U
                       Positive >25.0 U
Antibodies to soluble liver antigen (SLA) appear to be directed against the UGA-suppressor tRNA associated protein. These antibodies are highly specific for autoimmune hepatitis (AIH) and may rarely, be the only autoantibodies detected in serum from such patients. Antibodies to SLA are most closely associated with AIH type 1; the presence of these antibodies in patients with cryptogenic hepatitis suggests that these patients may have AIH type 1.
Anti-SLA antibodies may be detected in some patients with the primary biliary cirrhosis-AIH overlap syndrome, but not in healthy controls.
Day(s) Performed
Wednesday
Report Available
2 to 13 daysPerforming Laboratory
Quest Diagnostics Nichols InstituteCPT Code Information
83520
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| FSLAA | SLA Autoantibody | 32219-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| FSLAA | SLA Autoantibody | 32219-8 |
NY State Approved
YesMethod Name
Enzyme Linked Immunosorbent Immunoassay (ELISA)
Clinical Information
Anti-soluble liver antigen antibodies are detected in 10-30% of patients with type 1 autoimmune hepatitis (AIH), but not in patients with type 2 AIH, primary sclerosing cholangitis or primary biliary cirrhosis. The antibody is directed against a UGA suppressor tRNA associated protein. In some patients with AIH, this antibody may be the only autoantibody detected by current assays.
Secondary ID
57735Forms
If not ordering electronically, complete, print, and send Gastroenterology and Hepatology Client Test Request (T728) with the specimen.