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HelpTest Code LAB1234635 Lipoprotein (a) and Low-Density Lipoprotein Cholesterol, Serum
Specimen Required
Patient Preparation:
1. Fasting (8 hours) required
2. Patient must abstain from alcohol for 24 hours before collection.
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 4 mL
Collection Instructions:
1. Centrifuge and aliquot serum into a plastic vial.
2. Send refrigerated.
Useful For
Evaluation of the contribution of lipoprotein (a) (Lp[a])-cholesterol within measured low-density lipoprotein cholesterol
Evaluation of increased risk for cardiovascular disease and events:
-Most appropriately measured in individuals at intermediate risk for cardiovascular disease
-Patients with early atherosclerosis or strong family history of early atherosclerosis without explanation by traditional risk factors should also be considered for testing
-Follow-up evaluation of patients with elevations in Lp(a) mass
Reporting Name
Lp(a) and LDL Cholesterol, SSpecimen Type
SerumSpecimen Minimum Volume
2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 7 days | |
| Frozen | 60 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | Reject |
Reference Values
Lipoprotein (a) Cholesterol: Normal: <5 mg/dL
Lipoprotein-X: Undetectable
Low-Density Lipoprotein Cholesterol (LDL-C):
The National Lipid Association and the National Cholesterol Education Program (NCEP) have set the following guidelines for LDL-C in adults (ages 18 years and older):
Desirable: <100 mg/dL
Above desirable: 100-129 mg/dL
Borderline high: 130-159 mg/dL
High: 160-189 mg/dL
Very high: ≥190 mg/dL
The Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents has set the following guidelines for LDL-C in children and adolescents (ages 2-17 years):
Acceptable: <110 mg/dL
Borderline high: 110-129 mg/dL
High: ≥130 mg/dL
Supportive Data
Interpretation of low-density lipoprotein cholesterol (LDL-C) can be confounded in cases with elevated lipoprotein (a) (Lp[a]) expression because the cholesterol within Lp(a) is usually indistinguishable from the cholesterol within LDL. Accurate LDL-C measurements are critical for identifying genetic dyslipidemias such as familial hypercholesterolemia (FH). The interpretation of LDL-C, particularly in FH diagnostic algorithms may be affected by Lp(a)-C content.(1). Therefore, this panel reports the total measured LDL-C, the Lp(a)-C, and the LDL-C corrected for Lp(a)-C content.
Day(s) Performed
Monday through Thursday, Sunday
Report Available
3 to 4 daysSpecimen Retention Time
7 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
83700
83701
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| LPALD | Lp(a) and LDL Cholesterol, S | 100732-7 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 2849 | Lp(a) Cholesterol | 35388-8 |
| 23924 | LpX | 42178-4 |
| 614917 | LDL Chol (Beta-Quantification), S | 18261-8 |
| 610767 | LDL-C Corrected for Lp(a)-C | 100733-5 |
Forms
If not ordering electronically, complete, print, and send a Cardiovascular Test Request Form (T724) with the specimen.