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HelpTest Code LAB1231919 Cystinuria Profile, Quantitative, 24 Hour, Urine
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Reporting Name
Cystinuria Profile, QN, 24 hourSpecimen Type
UrineNecessary Information
1. 24-Hour volume (in milliliters) is required.
2. Patient's age is required.
3. Include family history, clinical condition (asymptomatic or acute episode), diet, and drug therapy information.
Specimen Required
-Urine Tubes, 10 mL (T068)
-Diazolidinyl Urea (Germall) 5.0 mL (T822)
Specimen Volume: 5 mL
Collection Instructions:
1. Collect before intravenous pyelogram.
2. Add 5 g of diazolidinyl urea (Germall) as preservative at start of collection. If preservative is not available, refrigerate during collection.
3. Collect urine for 24 hours.
4. Mix well before taking 5-mL aliquot.
Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens for multiple collections.
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Urine | Frozen (preferred) | 70 days |
| Refrigerated | 14 days |
Specimen Minimum Volume
1 mL
Special Instructions
Day(s) Performed
Monday through Friday
Specimen Retention Time
2 weeksReport Available
3 to 5 daysReference Values
Cystine
3-15 years: ≤53 mcmol/24 h
≥16 years: ≤115 mcmol/24 h
Lysine
3-15 years: ≤140 mcmol/24 h
≥16 years: ≤290 mcmol/24 h
Ornithine
3-15 years: ≤16 mcmol/24 h
≥16 years: ≤70 mcmol/24 h
Arginine
3-15 years: ≤25 mcmol/24 h
≥16 years: ≤64 mcmol/24 h
Conversion Formulas:
Result in mcmol/24 hours x 0.24 =result in mg/24 h
Result in mg/24 hours x 4.17 =result in mcmol/24 h
Useful For
Diagnosis of cystinuria using 24-hour urine collections
CPT Code Information
82136
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CYSQN | Cystinuria Profile, QN, 24 hour | 90785-7 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| TM38 | Collection Duration | 13362-9 |
| VL36 | Urine Volume | 3167-4 |
| 3583 | Cystine | 13966-7 |
| 3589 | Lysine | 25464-9 |
| 3590 | Ornithine | 25491-2 |
| 3591 | Arginine | 25322-9 |
| 50447 | Reviewed By | 18771-6 |
Method Description
Quantitative analysis of amino acids is performed by liquid chromatography tandem mass spectrometry. Patient samples are combined with isotopically labeled internal standard. Following protein precipitation, the supernatant is subjected to hydrophilic-interaction liquid chromatography for the separation of isomers with MS/MS detection of the underivatized amino acids.(Unpublished Mayo method)
Disease States
- Cystinuria
Genetics Test Information
This test provides a biochemical diagnosis of cystinuria through the measurement of cystine, lysine, ornithine, and arginine.
Forms
If not ordering electronically, complete, print, and send a Biochemical Genetics Test Request (T798) with the specimen.