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HelpTest Code LAB1231733 Oligoclonal Banding, Serum and Spinal Fluid
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Reporting Name
Oligoclonal BandingSpecimen Type
CSFSerum
Specimen Required
Both serum and spinal fluid are required. Spinal fluid must be obtained within 7 days of serum collection.
Specimen Type: Serum
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions:
1. Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.
2. Label specimen as serum.
Specimen Type: Spinal fluid
Container/Tube: Sterile vial
Specimen Volume: 0.5 mL
Collection Instructions: Label specimen as spinal fluid.
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| CSF | Refrigerated (preferred) | 14 days |
| Ambient | 14 days | |
| Frozen | 14 days | |
| Serum | Refrigerated (preferred) | 14 days |
| Ambient | 14 days | |
| Frozen | 14 days |
Specimen Minimum Volume
Serum, Spinal fluid: 0.4 mL
Day(s) Performed
Monday through Friday
Specimen Retention Time
14 daysReport Available
4 to 7 daysReference Values
CSF Oligoclonal Bands Interpretation: <2 bands
Useful For
Diagnosis of multiple sclerosis; especially useful in patients with equivocal clinical presentation and radiological findings
CPT Code Information
83916 x 2
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| OLIG | Oligoclonal Banding | 100757-4 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 8017 | CSF Bands | 49852-7 |
| 2783 | Serum Bands | 100755-8 |
| 23611 | CSF Olig Bands Interpretation | 100756-6 |
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| OLIGS | Serum Bands | No | Yes |
| OLIGC | CSF Bands | No | Yes |
Supportive Data
In a cohort of 1307 patients analyzed in 2018, where 159 had demyelinating disease, the Mayo Clinic oligoclonal banding test had a clinical sensitivity of 74% and clinical specificity of 89%, with an area under the ROC curve of 0.813 when 2 or more unique cerebrospinal fluid bands are used as a cutoff for positive.