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HelpTest Code LAB1230194 CD4 T-Cell Recent Thymic Emigrants, Blood
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Reporting Name
CD4 RTE, Flow CytometrySpecimen Type
Whole Blood EDTAShipping Instructions
Testing is performed Monday through Friday. Specimens not received by 4 p.m. (CST) on Friday may be canceled.
Samples arriving on the weekend and observed holidays may be canceled.
Collect and package specimen as close to shipping time as possible. Ship specimen overnight in an Ambient Shipping Box-Critical Specimens Only (T668) following the instructions in the box.
It is recommended that specimens arrive within 24 hours of collection.
Necessary Information
Ordering healthcare professional name and phone number are required.
Specimen Required
Supplies: Ambient Shipping Box-Critical Specimens Only (T668)
Container/Tube: Lavender top (EDTA)
Specimen Volume: 3 mL
Collection Instructions: Send whole blood specimen in original tube. Do not aliquot.
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Whole Blood EDTA | Ambient | 48 hours | PURPLE OR PINK TOP/EDTA |
Specimen Minimum Volume
1.5 mL
Special Instructions
Day(s) Performed
Monday through Friday
Specimen Retention Time
4 daysReport Available
3 to 4 daysReference Values
CD4 Absolute
Males
1 month-17 years: 153-1745 cells/mcL
18-70 years: 290-1,175 cells/mcL
Reference values have not been established for patients that are younger than 30 days of age.
Reference values have not been established for patients that are older than 70 years of age.
Females
1 month-17 years: 582-1630 cells/mcL
18-70 years: 457-1,766 cells/mcL
Reference values have not been established for patients that are younger than 30 days of age.
Reference values have not been established for patients that are older than 70 years of age.
CD4 RTE %
Males
1 month-17 years: 19.4-60.9%
18-25 years: 6.4-51.0%
26-55 years: 6.4-41.7%
≥56 years: 6.4-27.7%
Reference values have not been established for patients that are younger than 30 days of age.
Reference values have not been established for patients that are older than 70 years of age.
Females
1 month-17 years: 25.8-68.0%
18-25 years: 6.4-51.0%
26-55 years: 6.4-41.7%
≥56 years: 6.4-27.7%
Reference values have not been established for patients that are younger than 30 days of age.
Reference values have not been established for patients that are older than 70 years of age.
CD4 RTE Absolute
Males
1 month-17 years: 50.0-926.0 cells/mcL
18-70 years: 42.0-399.0 cells/mcL
Reference values have not been established for patients that are younger than 30 days of age.
Reference values have not been established for patients that are older than 70 years of age.
Females
1 month-17 years: 170.0-1007.0 cells/mcL
18-70 years: 42.0-832.0 cells/mcL
Reference values have not been established for patients that are younger than 30 days of age.
Reference values have not been established for patients that are older than 70 years of age.
Useful For
Evaluating thymic reconstitution in patients following hematopoietic cell transplantation, chemotherapy, immunomodulatory therapy, and immunosuppression
Evaluating thymic recovery in patients who are HIV-positive and on highly active antiretroviral therapy
Evaluating thymic output in patients with DiGeorge syndrome or other cellular immunodeficiencies
Assessing the naive T-cell compartment in a variety of immunological contexts (autoimmunity, cancer, immunodeficiency, and transplantation)
Identification of thymic remnants post-thymectomy for malignant thymoma or as an indicator of relapse of disease (malignant thymoma) or other contexts of thymectomy
Testing Algorithm
For information see Newborn Screen Follow-up for Severe Combined Immunodeficiency Syndrome (SCID).
CPT Code Information
86356
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CD4RT | CD4 RTE, Flow Cytometry | In Process |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 89504 | CD4 Absolute (cells/uL) | 24467-3 |
| 29536 | CD4 RTE % | 8123-2 |
| 29535 | CD4 RTE Absolute | 24467-3 |
| 29178 | Interpretation | 69052-9 |
Supportive Data
CD4 recent thymic emigrant (RTE) pediatric reference values (95% confidence intervals) were obtained by evaluating 90 healthy individuals, aged 1 month to 17 years. There was no significant age relationship for CD4 RTE. Gender relationships for CD4 RTE were significant at the 50th percentile (p≤0.0001). Adult reference values (95% confidence intervals) were obtained by evaluating 168 healthy adults, aged 18 to 70 years. There were significant age relationships for CD4 RTE as % CD4 T-cells.