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HelpTest Code LAB1176 Mitochondrial Antibodies (M2), Serum
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Reporting Name
Mitochondrial Ab, M2, SSpecimen Type
SerumSpecimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | OK |
| Heat-treated specimens | Reject |
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 21 days | |
| Frozen | 21 days |
Specimen Minimum Volume
0.4 mL
Day(s) Performed
Monday through Saturday
Specimen Retention Time
14 daysReport Available
2 to 3 daysReference Values
Negative: <0.1 Units
Borderline: 0.1-0.3 Units
Weakly positive: 0.4-0.9 Units
Positive: ≥1.0 Units
Reference values apply to all ages.
Useful For
Establishing the diagnosis of primary biliary cholangitis
This test is not useful for indicating the stage or prognosis of the disease or for monitoring the course of the disease.
CPT Code Information
86381
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| AMA | Mitochondrial Ab, M2, S | 51715-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| AMA | Mitochondrial Ab, M2, S | 51715-1 |
Supportive Data
Testing performed in the Antibody Immunology Laboratory of the antimitochondrial antibody-M2 by enzyme immunoassay (EIA) revealed a false-positive rate of less than 2% in 196 normal samples, and overall concordance compared with indirect immunofluorescence (IFA) of 90% on sera from the Mayo primary biliary cholangitis (PBC) Serum Bank. Ten discordant results were obtained (negative by EIA and positive by IFA). Seven of the 10 patients had no histologic evidence of PBC on liver biopsy.
Forms
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-General Request (T239)