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Test Code DIRLDL/LAB102 LDL, Direct (Low Density Lipoprotein)

Performing Laboratory

Asante Rogue Regional Medical Center

Specimen Requirements

Yellow (Gold) top tube (SST)

Lithium Heparin Green top tube


Outpatient clients MUST draw SST

Specimen Transport Temperature and Stability

Tubes of blood should be kept closed at all times in a vertical, stopper-up postion. Serum or plasma should be separated from contact with cells as soon as possible.  A maximum limit of 2 hours from the time of collection is recommended.

Separated serum should not remain at 15° to 30° C longer than 8 hours. If assays are not completed within 8 hours, serum should be stored at 2° to 8°C.  If assays are not completed within 48 hours, or the separated sample is to be stored beyone 48 hours, samples should be frozen at 15° to 20°C.  Frozen samples should be thawed only once.  Analyte deterioration may occur in samples that are repeatedly frozen and thawed.

Specimen Minimum Volume

2.0 mL

Reasons for Rejection




Quantity not sufficient (QNS)

Lack of Two Patient Identifiers:

         1-Patient’s First & Last name 

         2-Patient’s Date of Birth

Day(s) Test Set Up

Monday through Sunday

Additional Information

Medical trials and research have identified elevated LDL cholesterol as a major cause of coronary heart  disease (CHD).  Recent clinical studies have shown that LDL-lowering therapy reduces risk for CHD.  For these reasons, LDL cholesterol is often the primary target of cholesterol-lowering therapy.


Note:  Previous to the introduction of direct methods, the only way to easily estimate the LDL fraction was to measure total cholesterol, HDL and triglycerides and calculate LDL by the Friedenwald equation: 

Total cholesterol – HDL – (Trig/5).  Direct LDL methods allow the analysis of LDL alone.  In addition, high triglyceride values and non-fasting patients can have erroneous LDL values when calculated by the Friedenwald equation.


Homogeneous detergent assay 

Performing Department


Test Classification and CPT Coding


Lipoprotein, direct measurement; LDL cholesterol

Billing Code