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Test Code CD40 B-Cell CD40 Expression by Flow Cytometry, Blood

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Reporting Name

CD40 by Flow, QL, B

Specimen Type

Whole Blood EDTA


Ordering Guidance


This test is not used to detect in CD40L expression (CD154), which is responsible for X-linked hyper-IgM syndrome (HIGM1); see XHIM / X-Linked Hyper IgM Syndrome, Blood.



Shipping Instructions


Testing performed Monday through Friday. Specimens not received by 4pm (CST) on Friday may be cancelled.

 

Collect and package specimen as close to shipping time as possible. It is recommended that specimens arrive within 24 hours of collection.

 

Samples arriving on the weekend and observed holidays may be canceled.



Necessary Information


Ordering healthcare professional name and phone number are required.



Specimen Required


Container/Tube: Lavender top (EDTA)

Specimen Volume: 3 mL

Collection Instructions: Send whole blood specimen in original tube. Do not aliquot.

Additional Information: For serial monitoring, it is recommended that specimens are collected at the same time of day.


Reject Due To

Gross hemolysis Reject
Gross lipemia Reject

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole Blood EDTA Ambient 72 hours PURPLE OR PINK TOP/EDTA

Specimen Minimum Volume

1 mL

Day(s) Performed

Monday through Friday

Specimen Retention Time

4 days

Report Available

3 to 4 days

Reference Values

Present (normal)

Useful For

Evaluating patients for hyper-IgM type 3 (HIGM3) syndrome due to defects in CD40, typically seen in patients less than 10 years

 

Assessing B-cell immune competence in other clinical contexts, including autoimmunity, malignancy, and transplantation

CPT Code Information

88184

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CD40 CD40 by Flow, QL, B 104694-5

 

Result ID Test Result Name Result LOINC Value
89009 CD40 by Flow, QL, B 104694-5

Genetics Test Information

Homozygous variants in the CD40 gene cause autosomal recessive hyper-IgM syndrome type 3. The CD40 gene is located on chromosome 20q12-q13.2.