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HelpTest Code BARQ BCR::ABL1, Rare Fusion Monitoring, Quantitative, Varies
Ordering Guidance
This test should not be used to screen for BCR::ABL1 fusions at the time of diagnosis. For diagnostic evaluation, please order BADX / BCR/ABL1, Qualitative, Diagnostic Assay, Varies; or BCRFX / BCR/ABL1 Qualitative Diagnostic Assay with Reflex to BCR/ABL1 p190 Quantitative Assay or p210 Quantitative Assay, Varies.
For measurable residual disease (MRD) monitoring of patients with chronic myeloid leukemia (CML) or, less commonly, B-cell acute lymphoblastic leukemia (B-ALL) or acute myeloid leukemia (AML) with a previously identified p210 (e13/e14-a2) fusion transcript, order BCRAB / BCR/ABL1, p210, mRNA Detection, Reverse Transcription-PCR (RT-PCR), Quantitative, Monitoring Chronic Myelogenous Leukemia (CML), Varies.
For MRD monitoring of B-ALL or rare CML or AML patients with a previously identified p190 (e1-a2) fusion transcript, order BA190 test / BCR/ABL1, p190, mRNA Detection, Reverse Transcription-PCR (RT-PCR), Quantitative, Monitoring Assay, Varies.
For more information, see BCR/ABL1 Ordering Guide for Blood and Bone Marrow
Shipping Instructions
Ambient specimens must arrive within 3 days (72 hours) of collection. Refrigerated specimens must arrive within 5 days of collection. Collect and package specimens as close to shipping time as possible.
Necessary Information
The following information is required:
1. Pertinent clinical history including if the patient has a diagnosis of chronic myeloid leukemia, B-cell acute lymphoblastic leukemia, or other BCR::ABL1-positive neoplasm
2. Specific fusion transcript if previously determined
3. Date of collection
4. Specimen source (blood or bone marrow)
Specimen Required
Submit only 1 of the following specimens:
Specimen Type: Whole blood
Container/Tube:
Preferred: Lavender top (EDTA)
Acceptable: Yellow top (ACD)
Specimen Volume: 10 mL
Collection Instructions:
1. Invert several times to mix blood.
2. Send whole blood specimen in original tube. Do not aliquot.
3. Label specimen as blood.
Specimen Type: Bone marrow
Container/Tube:
Preferred: Lavender top (EDTA)
Acceptable: Yellow top (ACD)
Specimen Volume: 4 mL
Collection Instructions:
1. Invert several times to mix bone marrow.
2. Send bone marrow specimen in original tube. Do not aliquot.
3. Label specimen as bone marrow.
Forms
1. Hematopathology Patient Information (T676)
2. If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request (T726) with the specimen.
Useful For
Quantitative monitoring of rare (non-p210 [non-E13/E14A2], non-p190 [non-E1A2]) BCR::ABL1 fusion transcript types occurring in myeloid neoplasms (eg, CML, myeloproliferative neoplasms) or B-cell acute lymphoblastic leukemias.
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| BADX | BCR/ABL1, RNA-Qual, Diagnostic | Yes | No |
| BA190 | BCR/ABL1, p190, Quant, Monitor | Yes | No |
| BCRAB | BCR/ABL1, p210, Quant, Monitor | Yes | No |
Testing Algorithm
If a previous BCR::ABL1 rare fusion has not been identified by Mayo Clinic Laboratories (MCL), the qualitative, diagnostic assay for BCR::ABL1 will be performed at an additional charge to identify the fusion form.
If MCL has previously identified a p190 or p210 BCR::ABL1 fusion form, the appropriate quantitative testing will be performed and this test will be canceled.
Reporting Name
BCR::ABL1 Rare fusion Quant MonitorSpecimen Type
VariesSpecimen Minimum Volume
Whole blood: 8 mL; Bone marrow: 2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Varies | Refrigerated (preferred) | 5 days | PURPLE OR PINK TOP/EDTA |
| Ambient | 72 hours | PURPLE OR PINK TOP/EDTA |
Reject Due To
| Gross hemolysis | Reject |
| Moderately or severely clotted | Reject |
Reference Values
An interpretive report will be provided
Day(s) Performed
Weekly
Report Available
10 to 15 daysSpecimen Retention Time
Whole blood, Bone marrow: 2 weeks; Extracted RNA: 3 monthsPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
81208
BADX: 81206, 81207, 81208 (if appropriate)
BA190: 81207 (if appropriate)
BCRAB: 81206 (if appropriate)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| BARQ | BCR::ABL1 Rare fusion Quant Monitor | 75892-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| MP097 | Specimen Type | 31208-2 |
| MP098 | BCRABL Fusion | 75892-0 |
| 623494 | Signing Pathologist | 18771-6 |
| 623479 | Interpretation | 69047-9 |