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Test Code PBHA Lead, Hair

Performing Laboratory

Mayo Medical Laboratories in Rochester

Reporting Name

Lead, Hair

Specimen Type

Hair


Specimen Required


Supplies: Hair and Nails Collection Kit (T565)

Specimen Volume: 0.2 g

Collection Instructions: Prepare and transport specimen per the instructions in the kit or see Collecting Hair and Nails for Metals Testing in Special Instructions.

Additional Information: If known, indicate source of hair (axillary, head, or pubic).


Reject Due To

Hemolysis

NA

Lipemia

NA

Icterus

NA

Other

NA

Specimen Stability Information

Specimen Type Temperature Time
Hair Ambient (preferred)
  Frozen 
  Refrigerated 

Specimen Minimum Volume

0.05 g

Day(s) and Time(s) Performed

Tuesday; 3 p.m.

Specimen Retention Time

14 days

Analytic Time

2 days

Reference Values

0.0-3.9 mcg/g of hair

Reference values apply to all ages.

Useful For

Detecting lead exposure in hair specimens

Method Name

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

83655

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PBHA Lead, Hair 5673-9

 

Result ID Test Result Name Result LOINC Value
31898 Lead, Hair 5673-9
PBHSC Specimen Source 31208-2

Clinical Information

Hair analysis for lead can be used to corroborate blood analysis or to document past lead exposure. If the hair is collected and segmented in a time sequence (based on length from root), the approximate time of exposure can be assessed.

Interpretation

Normal hair lead content is below 5.0 mcg/g. Hair lead content above 10.0 mcg/g indicates significant lead exposure.

Cautions

Blood lead analysis has the strongest correlation with toxicity.

Clinical Reference

1. Strumylaite L, Ryselis S, Kregzdyte R: Content of lead in human hair from people exposed to lead. Int J Hyg Environ Health 2004;207:345-351

2. Barbosa F, Tanus-Santos J, Gerlach R, Parsons P: A Critical review of biomarkers used for monitoring human exposure to lead: advantages, limitations, and future needs. Environ Health Perspect 2005;113:1669-1674

3. Sanna E, Liguori A, Palmes L, et al: Blood and hair lead levels in boys and girls living in two Sardinian towns at different risks of lead pollution. Ecotoxicol Environ Saf 2003;55:293-299

Method Description

Arsenic, mercury, and lead in hair are analyzed by inductively coupled plasma-mass spectrometry (ICP-MS) in kinetic energy discrimination (KED) mode using gallium, iridium, and lutetium as internal standards, and a salt matrix calibration.(Unpublished Mayo method)